Budesonide, the active ingredient in Budecort 100 Inhaler, is a corticosteroid that can potentially affect the immune system when used long-term. Corticosteroids like budesonide work by reducing inflammation, which is an important part of the immune response. While Budecort is generally safe when used as directed, it can sometimes make users more susceptible to infections like the flu, common cold, and chest infections. This is because budesonide can slightly weaken the immune system, especially with prolonged use.

However, the risk of immunosuppression is lower with inhaled corticosteroids like Budecort compared to oral steroids, as the medication is delivered directly to the lungs and only a small amount is absorbed systemically. Studies have also shown that budesonide, when combined with the bronchodilator formoterol, can inhibit early innate antiviral immune responses in circulating blood cells. This suggests that while Budecort may have some immunosuppressive effects, it is still an effective treatment for managing asthma and COPD symptoms. Patients should inform their doctor of any infections or immune system concerns before starting Budecort, and monitor for signs of increased susceptibility to illness while using it.