Tadalafil, often found in medications like Femalefil, has a relatively long half-life of about 17.5 hours. This means that the effects of Tadalafil can last for up to 36 hours in the body. Tadalafil Femalefil usually takes about 30 minutes to 1 hour to start working. While the peak effect occurs within the first few hours, the drug can remain active in the body for an extended period, allowing for greater spontaneity in sexual activity. Individual factors such as metabolism, age, and overall health can influence how long Tadalafil lingers in the body.